PI3 Kinase p85 alpha (3H5) Mouse Monoclonal Antibody

PI3 Kinase p85 alpha (3H5) Mouse Monoclonal Antibody

Size1:50μL Price1:$150
Size2:100μL Price2:$280
Size3:200μL Price3:$520
Application:WB,IHC-P
Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:PIK3R1 SKU: AMM03618 Category: Mouse Monoclonal Antibody Tags: , , , , , , ,

Summary

Production Name

PI3 Kinase p85 alpha (3H5) Mouse Monoclonal Antibody

Description

Mouse Monoclonal Antibody

Host

Mouse

Application

WB,IHC-P

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG1

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification

Affinity Purification

 

Immunogen

Gene Name

PIK3R1

Alternative Names

PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha

Gene ID

5295

SwissProt ID

P27986

 

Application

Dilution Ratio

WB: 1:500-1:1000 IHC: 1:50-1:100

Molecular Weight

Calculated MW: 84 kDa; Observed MW: 84 kDa

 

Background

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.

 

Research Area

Signal Transduction

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