ALKB1_MOUSE P0CB42
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UniProt:P0CB42
Recommended name：Nucleic acid dioxygenase ALKBH1
EC number：EC 1.14.11.-
Alternative names：(Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase ALKBH1) (DNA lyase ABH1) (DNA oxidative demethylase ALKBH1) (mRNA N(3)-methylcytidine demethylase) (tRNA N1-methyl adenine demethylase) (EC 1.14.11.-)
Cleaved into：
GeneID：211064
Gene names (primary )：Alkbh1
Gene names (synonym )：Abh Alkbh
Gene names (ORF )：
Length：389
Mass：43746
Sequence：MGKMAAAVASLATLAAEPREDAFRKLFRFYRQSRPGTADLGAVIDFSEAHLARSPKPGVPQVVRFPLNVSSVTERDAERVGLEPVSKWRAYGLEGYPGFIFIPNPFLPGCQRHWVKQCLKLYSQKPNVCNLDKHMTKEETQGLWEQSKEVLRSKEVTKRRPRSLLERLRWVTLGYHYNWDSKKYSADHYTPFPSDLAFLSEQVATACGFQGFQAEAGILNYYRLDSTLGIHVDRSELDHSKPLLSFSFGQSAIFLLGGLKRDEAPTAMFMHSGDIMVMSGFSRLLNHAVPRVLPHPDGECLPHCLETPLPAVLPSNSLVEPCSVEDWQVCATYLRTARVNMTVRQVLATGQDFPLEPVEETKRDIAADGLCHLHDPNSPVKRKRLNPNS
Tissue specificity：In adult organs, highly expressed in testis, eye, brain and kidney. {ECO:0000269|PubMed:21072209}.
Induction：
Developmental stage：Weak expression throughout the embryo at 8.5 dpc. As the cells migrate and differentiate during organogenesis, expressed in the spinal cord, forebrain and branchial arches at 9.5 dpc, and also in limb buds at 10.5 dpc. Peak expression at 11.5 dpc in the frontonasal process including telencephalon, maxillary, mandibular and hyoid arches, upper and lower limb buds and midbrain and rhombomere 1 roof plates. Expression decreases considerably from 11.5 dpc to 12.5 dpc (PubMed:21072209). At 8.5 dpc is highly expressed in the chorion and the ectoplacental cone. At 10.5 dpc is highly expressed in multiple trophoblast lineages (spongiotrophoblasts, giant cell trophoblasts, glycogen cells, and labyrinthine trophoblasts). The highest placental level is at 9.5 dpc and subsequently decreases until parturition (PubMed:18163532). {ECO:0000269|PubMed:18163532, ECO:0000269|PubMed:21072209}.
Protein families：