PIMRE_MOUSE Q8BFY7
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UniProt:Q8BFY7
Recommended name:Protein PIMREG
EC number:
Alternative names:(CALM-interactor expressed in thymus and spleen homolog) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1)
Cleaved into:
GeneID:109212
Gene names (primary ):Pimreg
Gene names (synonym ):Cats Fam64a Rcs1
Gene names (ORF ):
Length:231
Mass:25686
Sequence:MASQWQGMRTSVRRRSLLKEEQLEKKEVTRSAGGHPETGPLGSLCRQFQRRLPLRAVSLNLGNGPSWKRLESPEPEQQGLQAAARSAKSALGAMSQRIQESCQSGTKWLMETQVKVRRKRGAQKDRGSPPPSLSQKNTRLCRANRDARVGGHLRLSGQMGPHAHRRQRLRRESALRSPCSSTEPLCSPSESDSDLEPVGAGIQHLQKLSQRLDRAIKAEESGDMTVSLIRE
Tissue specificity:Mainly expressed in thymus and ovary. Expressed in all T-cell subpopulations isolated from the thymus, macrophages, pro-erythrocytes, granulocytes, mast cells and progenitor cells. {ECO:0000269|PubMed:19383357}.
Induction:
Developmental stage:Widely expressed at 9.5 dpc, including high levels in the neural tube, somites, the posterior region of the midbrain, olfactory placode and the branchial arches. At 10.5 dpc, reduction of the widespread expression and stronger expression in the neural tube, branchial arches, developing limbs, telencephalon, nasal process, lense vesicle, anterior and posterior regions of the mid- and hindbrain. From 11.5 dpc on, strongly expressed in the genital tubercle and hair and vibrissae follicles. From 12.5 dpc onwards, expression decreases, with a complete lack of expression in the cephalic region and the neural tube at 14.5 dpc. Strongly expressed during limb development, with higher levels in hindlimbs compared to forelimbs and expression slightly more marked in the posterior region of the limb buds. At 11.5 and 12.5 dpc, detected at the distal domain and the underlying mesenchyme, but not in the apical ectodermal ridge. Distally, becomes confined to the digits at 13.5 and 14.5 dpc. {ECO:0000269|PubMed:19383357}.
Protein families: