| Name | Recombinant Mouse FZD2 (C-Fc) |
| Purity | Greater than 95% as determined by reducing SDS-PAGE |
| Endotoxin level | <1 EU/µg as determined by LAL test. |
| Construction | Recombinant Mouse Frizzled (Drosophila) Homolog 2 is produced by our Mammalian expression system and the target gene encoding Gln29-Leu168 is expressed with a human IgG1 Fc tag at the C-terminus. |
| Accession # | Q9JIP6 |
| Host | Human Cells |
| Species | Mouse |
| Predicted Molecular Mass | 42.9 KDa |
| Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, 8% Trehaolse, 0.02% tween 80, pH7.4. |
| Form | Lyophilized |
| Shipping | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| Stability&Storage | Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Alternative Names
Frizzled-2; Fz-2; mFz2; Fzd2;frizzled (Drosophila) homolog 2
Background
Wnt signaling plays a critical role in embryonic development, and genetic aberrations. Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines and in high-grade tumors and that their expression correlates with markers of epithelial-mesenchymal transition (EMT). It is also shown that Frizzled-2 expression is greater in embryonic than adult tissues, with heart, brain, lung, kidney and gut showing the highest levels.
Note
For Research Use Only , Not for Diagnostic Use.
