| Name | Recombinant Human DLL3 (C-6His) |
| Purity | Greater than 95% as determined by reducing SDS-PAGE |
| Endotoxin level | <1 EU/µg as determined by LAL test. |
| Construction | Recombinant Human Delta-like protein 3 is produced by our Mammalian expression system and the target gene encoding Ala27-Leu492 is expressed with a 6His tag at the C-terminus. |
| Accession # | Q9NYJ7 |
| Host | Human Cells |
| Species | Human |
| Predicted Molecular Mass | 49.4 KDa |
| Buffer | Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 150 mM NaCl, 0.1 M Glycine, 0.2 M Arg, 5% Trehalose, pH7.5. |
| Form | Liquid |
| Shipping | The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| Stability&Storage | Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Alternative Names
Delta-like protein 3; Drosophila Delta homolog 3; Delta3; DLL3
Background
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 is highly expressed in tumor cells and could be involved in the modification of tumor (immune) microenvironment. Neuroendocrine carcinomas are very aggressive tumors with few treatment options. DLL3 seems to be an optimal target for therapeutic intervention, as it is expressed mainly on the membrane of tumor cells with neuroendocrine origin.
Note
For Research Use Only , Not for Diagnostic Use.
