Summary
Performance
Immunogen
Application
Background
Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking. E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys- 48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
Research Area
