Summary
Performance
Immunogen
Application
Background
This gene belongs to the cytidylyltransferase family and is involved in the regulation of phosphatidylcholine biosynthesis. Mutations in this gene are associated with spondylometaphyseal dysplasia with cone-rod dystrophy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015],catalytic activity:CTP + choline phosphate = diphosphate + CDP-choline.,enzyme regulation:By phosphorylation.,function:Controls phosphatidylcholine synthesis.,pathway:Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.,PTM:The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation.,similarity:Belongs to the cytidylyltransferase family.,subcellular location:It can interconvert between an inactive cytosolic form and an active membrane-bound form.,subunit:Homodimer; disulfide-linked.,
Research Area
Glycerophospholipid metabolism;
