Recombinant Human OGG1

Recombinant Human OGG1

Size1:10μg price1:$136
Size2:50μg price2:$378
Size3:500μg price3:$1890 SKU: PEH1248 Category: Target Proteins Tags: ,

Datasheet

Name

Recombinant Human OGG1

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin level

<1 EU/µg as determined by LAL test.

Construction

Recombinant Human N-Glycosylase is produced by our E.coli expression system and the target gene encoding Met1-Gly345 is expressed.

Accession #

AAH00657.1

Host

E.coli

Species

Human

Predicted Molecular Mass

38.8 KDa

Buffer

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.5.

Form

Liquid

Shipping

The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below.

Stability&Storage

Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

 

 

 

Alternative Names

N-Glycosylase/DNA Lyase; 8-Oxoguanine DNA Glycosylase; DNA-(Apurinic or Apyrimidinic Site) Lyase; AP Lyase; OGG1; MMH; MUTM; OGH1

 

Background

Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.

 

Note

For Research Use Only , Not for Diagnostic Use.

 

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