Summary
| Production Name | Angiopoietin 1 Rabbit Polyclonal Antibody |
| Description | Rabbit Polyclonal Antibody |
| Host | Rabbit |
| Application | WB |
| Reactivity | Human,Rat |
Performance
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | IgG |
| Clonality | Polyclonal Antibody |
| Form | Liquid |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification | Affinity Chromatography |
Immunogen
| Gene Name | ANGPT1 |
| Alternative Names | ANGPT1; KIAA0003; Angiopoietin-1; ANG-1 |
| Gene ID | 284 |
| SwissProt ID | Q15389 |
Application
| Dilution Ratio | WB: 1:500-1:1000 |
| Molecular Weight | Calculated MW: 58 kDa; Observed MW: 58 kDa |
Background
Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context.
Research Area
Cancer
