KDM1A (1E5) Mouse Monoclonal Antibody

KDM1A (1E5) Mouse Monoclonal Antibody

Size1:50μl Price1:$168
Size2:100μl Price2:$300
Size3:500μl Price3:$1200 SKU: AMM03855 Category: Mouse Monoclonal Antibody Tags: , , , , ,

Datasheet

Summary

Production Name

KDM1A (1E5) Mouse Monoclonal Antibody

Description

Primary antibody

Host

Mouse

Application

WB,ICC/IF,IP

Reactivity

Human,Monkey

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG1

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification

Affinity Purified

 

Immunogen

Gene Name

KDM1A

Alternative Names

KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2

Gene ID

23028

SwissProt ID

O60341

 

Application

Dilution Ratio

WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

Molecular Weight

Calculated MW: 93 kDa; Observed MW: 110 kDa

 

Background

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.

 

Research Area

Epigenetics and Nuclear Signaling

Related products