SMC1A Mouse Monoclonal Antibody

SMC1A Mouse Monoclonal Antibody

Size1:50μl Price1:$168
Size2:100μl Price2:$300
Size3:500μl Price3:$1200 SKU: AMM00962 Category: Mouse Monoclonal Antibody Tags: , , , ,

Datasheet

Summary

Production Name

SMC1A Mouse Monoclonal Antibody

Description

Primary antibody

Host

Mouse

Application

WB

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG1

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification

Affinity Purified

 

Immunogen

Gene Name

SMC1A

Alternative Names

Chromosome segregation protein SmcB; DXS423E; KIAA0178; MGC138332; Sb1.8; Segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1 (structural maintenance of chromosomes 1 yeast) like 1; SMC1; SMC1 structural maintenance of chromosomes 1 like 1; SMC1A; SMC1A_HUMAN; SMC1alpha; SMC1L1; SMCB; Structural maintenance of chromosomes 1A; Structural maintenance of chromosomes protein 1A.

Gene ID

8243

SwissProt ID

Q14683

 

Application

Dilution Ratio

WB: 1/500-1/1000

Molecular Weight

Calculated MW: 143 kDa; Observed MW: 143 kDa

 

Background

Structural maintenance of chromosomes 1 (SMC1) protein is a chromosomal protein member of the cohesin complex that enables sister chromatid cohesion and plays a role in DNA repair . ATM/NBS1-dependent phosphorylation of SMC1 occurs at Ser957 and Ser966 in response to ionizing radiation (IR) as part of the intra-S-phase DNA damage checkpoint. SMC1 phosphorylation is ATM-independent in cells subjected to other forms of DNA damage, including UV light and hydroxyurea treatment.

 

Research Area

Cell Biology

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