KDM1A (1B2) Mouse Monoclonal Antibody

KDM1A (1B2) Mouse Monoclonal Antibody

Size1:50μl Price1:$150
Size2:100μl Price2:$280
Size3:500μl Price3:$1200 SKU: AMM03566 Category: Mouse Monoclonal Antibody Tags: , , , , , ,

Datasheet

Summary

Production Name

KDM1A (1B2) Mouse Monoclonal Antibody

Description

Primary antibody

Host

Mouse

Application

WB

Reactivity

Human,Mouse,Monkey

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG1

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification

Ascitic Fluid

 

Immunogen

Gene Name

KDM1A

Alternative Names

KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2

Gene ID

23028

SwissProt ID

O60341

 

Application

Dilution Ratio

WB: 1/500-1/1000

Molecular Weight

Calculated MW: 93 kDa; Observed MW: 93 kDa

 

Background

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.

 

Research Area

Epigenetics and Nuclear Signaling

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