Phospho-IRE1 (Ser724) Rabbit Monoclonal Antibody

Phospho-IRE1 (Ser724) Rabbit Monoclonal Antibody

Size1:50μL Price1:$188 $99
Size2:100μL Price2:$338 $180
Application:WB,IP
Reactivity:Human
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:ERN1 SKU: AMRe02857 Category: Rabbit Monoclonal Antibody Tags: , , , , , ,

Datasheet

Summary

Production Name

Phospho-IRE1 (Ser724) Rabbit Monoclonal Antibody

Description

Rabbit Monoclonal antibody

Host

Rabbit

Application

WB,IP

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Phosphorylated

Isotype

IgG

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification

Affinity Purification

 

Immunogen

Gene Name

ERN1

Alternative Names

ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a

Gene ID

2081

SwissProt ID

O75460

 

Application

Dilution Ratio

WB: 1:500-1:1000 IP: 1:20

Molecular Weight

Calculated MW: 110 kDa; Observed MW: 110 kDa

 

Background

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

 

Research Area

Signal Transduction

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