MARK3 (4Z8) Rabbit Monoclonal Antibody

MARK3 (4Z8) Rabbit Monoclonal Antibody

Size1:50μL Price1:$138
Size2:100μL Price2:$240
Size3:200μL Price3:$380
Application:WB,ICC/IF,FC,IP
Reactivity:Human,Mouse
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:MARK3 SKU: AMRe13650 Category: Rabbit Monoclonal Antibody Tags: , , , , , , , ,

Summary

Production Name

MARK3 (4Z8) Rabbit Monoclonal Antibody

Description

Rabbit Monoclonal Antibody

Host

Rabbit

Application

WB,ICC/IF,FC,IP

Reactivity

Human,Mouse

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Purification

Affinity purification

 

Immunogen

Gene Name

MARK3

Alternative Names

C-TAK1; cTAK1; Emk2; KP78; Mark3; PAR1A;

Gene ID

4140

SwissProt ID

P27448

 

Application

Dilution Ratio

WB 1:1000, ICC/IF 1:50-1:100, FCM 1:50, IP 1:20-1:100

Molecular Weight

84kDa

 

Background

Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).

 

Research Area

Related products