SHC Rabbit Monoclonal Antibody

SHC Rabbit Monoclonal Antibody

Size1:50μL Price1:$188
Size2:100μL Price2:$338
Application:WB, IHC-P
Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:SHC SKU: AMRe86908 Category: Rabbit Monoclonal Antibody Tags: , , , , , ,

Summary

Production Name

SHC Rabbit Monoclonal Antibody

Description

Rabbit Monoclonal antibody

Host

Rabbit

Application

WB, IHC-P

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification

Affinity Purification

 

Immunogen

Gene Name

SHC

Alternative Names

SHC; SHCA

Gene ID

6464

SwissProt ID

P29353

 

Application

Dilution Ratio

WB: 1:1000 IHC-P: 1:100-1:200

Molecular Weight

Calculated MW:63 kDa; Observed MW:46,52,66 kDa

 

Background

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

 

Research Area

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