SUFU Mouse Monoclonal Antibody

SUFU Mouse Monoclonal Antibody

Size1:50μL Price1:$168
Size2:100μL Price2:$300
Size3:200μL Price3:$380
Application:WB

Reactivity:Human, African Green Mouseonkey, Mouse
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge).
See other 26 conjugates.

Gene Name:SUFU
SKU: AMM86079 Category: Mouse Monoclonal Antibody Tags: , , , , ,

Summary

Production Name

SUFU Mouse Monoclonal Antibody

Description

Mouse Monoclonal Antibody

Host

Mouse

Application

WB

Reactivity

Human, African Green Mouseonkey, Mouse

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

Mouse IgG1

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

Purification

Affinity Purification

 

Immunogen

Gene Name

SUFU

Alternative Names

Suppressor of fused homolog, SUFUH, SUFU

Gene ID

51684

SwissProt ID

Q9UMX1

 

Application

Dilution Ratio

WB:1:2000

Molecular Weight

53.9kDa

 

Background

Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU- GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).

 

Research Area