USP2 Mouse Monoclonal Antibody

USP2 Mouse Monoclonal Antibody

Size1:50μL Price1:$168
Size2:100μL Price2:$300
Size3:200μL Price3:$380
Application:WB

Reactivity:Human, African Green Mouseonkey
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge).
See other 26 conjugates.

Gene Name:USP2
SKU: AMM86071 Category: Mouse Monoclonal Antibody Tags: , , , ,

Summary

Production Name

USP2 Mouse Monoclonal Antibody

Description

Mouse Monoclonal Antibody

Host

Mouse

Application

WB

Reactivity

Human, African Green Mouseonkey

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

Mouse IgG1

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

Purification

Affinity Purification

 

Immunogen

Gene Name

USP2

Alternative Names

Ubiquitin carboxyl-terminal hydrolase 2, 3.4.19.12, 41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2, USP2, UBP41

Gene ID

9099

SwissProt ID

O75604

 

Application

Dilution Ratio

WB:1:2000

Molecular Weight

68.7kDa

 

Background

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

 

Research Area