DCX Mouse Monoclonal Antibody

DCX Mouse Monoclonal Antibody

Size1:50μL Price1:$168
Size2:100μL Price2:$300
Application:WB,IHC,ICC,FC,ELISA

Reactivity:Human,Mouse,Rat,Rabbit,Monkey
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge).
See other 26 conjugates.

Gene Name:DCX
SKU: AMM81147 Category: Mouse Monoclonal Antibody Tags: , , , , , , , , , , ,

Summary

Production Name

DCX Mouse Monoclonal Antibody

Description

Mouse Monoclonal Antibody

Host

Mouse

Application

WB,IHC,ICC,FC,ELISA

Reactivity

Human,Mouse,Rat,Rabbit,Monkey

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

Mouse IgG1

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

Purification

Affinity Purification

 

Immunogen

Gene Name

DCX

Alternative Names

DC; DBCN; LISX; SCLH; XLIS

Gene ID

1641

SwissProt ID

O43602

 

Application

Dilution Ratio

WB:1:500-1:2000,IHC:1:200-1:1000,ICC:1:200-1:1000,FC:1:200-1:400,ELISA:1:10000

Molecular Weight

49.3kDa

 

Background

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

 

Research Area