AIF Mouse Monoclonal Antibody

AIF Mouse Monoclonal Antibody

Size1:50μL Price1:$168
Size2:100μL Price2:$300
Application:WB,IHC,ICC,FC,ELISA

Reactivity:Human,Mouse,Rat,,Monkey
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge).
See other 26 conjugates.

Gene Name:AIF
SKU: AMM81018 Category: Mouse Monoclonal Antibody Tags: , , , , , , , , , , ,

Summary

Production Name

AIF Mouse Monoclonal Antibody

Description

Mouse Monoclonal Antibody

Host

Mouse

Application

WB,IHC,ICC,FC,ELISA

Reactivity

Human,Mouse,Rat,,Monkey

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

Mouse IgG2b

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

Purification

Affinity Purification

 

Immunogen

Gene Name

AIF

Alternative Names

AIFM1; AIF; PDCD8; COXPD6; MGC111425

Gene ID

9131

SwissProt ID

O95831

 

Application

Dilution Ratio

WB:1:500-1:2000,IHC:1:200-1:1000,ICC:1:200-1:1000,FC:1:200-1:400,ELISA:1:10000

Molecular Weight

67kDa

 

Background

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10

 

Research Area

Apoptosis