NSUN5_MOUSE Q8K4F6
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UniProt:Q8K4F6
Recommended name：28S rRNA (cytosine-C(5))-methyltransferase
EC number：EC 2.1.1.-
Alternative names：(NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein homolog)
Cleaved into：
GeneID：100609
Gene names (primary )：Nsun5
Gene names (synonym )：Wbscr20a
Gene names (ORF )：
Length：465
Mass：51030
Sequence：MGLYAAAAAVLAGVESRQGSLKGLVYSSNFQNLKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLQESSRPGQAYQVPRFVRVNTLKTRPEDAIDYFKRQGFSYQGRASSLEDLRALKGQHFLLDPLLPELLVFPAQTDLHEHPLYRAGHLILQDKASCLPAMLLSPPPGSHVIDACAAPGNKTSYIAALLKNQGKIFAFDQDAKRLAAMATLVARAGVSCCELAEKDFLTVSPSDQRYSQVQYILLDPSCSGSGMLSRQLEEHGEGTPSKERLQALAGFQQRALCHALRFPSLQRLVYSTCSLCQEENEDVVQEALQHNSGTFRLAPVLPTWPHRGLSTFPGSEHCLRASPETTLTGGFFIAVFERAEVVPTPAPQTDAMDPEPLSQVPKRKRRRKAAVGASMQPST
Tissue specificity：In the hippocampus, specifically expressed in adult hippocampal NG2-positive oligodendrocyte precursor cells (at protein level). {ECO:0000269|PubMed:30485550}.
Induction：
Developmental stage：Present in the developing cerebral cortex from embryonic day (E) 12.5, with a peak at E14.5 followed by a decrease from E18.5 (at protein level) (PubMed:31462248). Selectively expressed in radial glial cells of cerebral cortex from E12.5 to E16.5, but not in intermediate progenitor cells (IPCs) or neocortical neurons (at protein level) (PubMed:31462248). Highly expressed in callosal oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs) from postnatal day 7 to postnatal day 28 (PubMed:31174389). {ECO:0000269|PubMed:31174389, ECO:0000269|PubMed:31462248}.
Protein families：Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family