4F2_MOUSE P10852
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UniProt:P10852
Recommended name：4F2 cell-surface antigen heavy chain
EC number：
Alternative names：(4F2hc) (Solute carrier family 3 member 2) (CD antigen CD98)
Cleaved into：
GeneID：17254
Gene names (primary )：Slc3a2
Gene names (synonym )：Mdu1
Gene names (ORF )：
Length：526
Mass：58337
Sequence：MSQDTEVDMKDVELNELEPEKQPMNAADGAAAGEKNGLVKIKVAEDETEAGVKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPVQRWWHKGALYRIGDLQAFVGRDAGGIAGLKSHLEYLSTLKVKGLVLGPIHKNQKDEINETDLKQINPTLGSQEDFKDLLQSAKKKSIHIILDLTPNYQGQNAWFLPAQADIVATKMKEALSSWLQDGVDGFQFRDVGKLMNAPLYLAEWQNITKNLSEDRLLIAGTESSDLQQIVNILESTSDLLLTSSYLSNSTFTGERTESLVTRFLNATGSQWCSWSVSQAGLLADFIPDHLLRLYQLLLFTLPGTPVFSYGDELGLQGALPGQPAKAPLMPWNESSIFHIPRPVSLNMTVKGQNEDPGSLLTQFRRLSDLRGKERSLLHGDFHALSSSPDLFSYIRHWDQNERYLVVLNFRDSGRSARLGASNLPAGISLPASAKLLLSTDSARQSREEDTSLKLENLSLNPYEGLLLQFPFVA
Tissue specificity：Detected on the surface of embryonic epithelial cells in the epidermis, thymus, kidney, intestine, brain choroid plexus, and in retina. Detected in adult and embryonic brain, spleen, kidney, intestine and liver, and in adult testis (at protein level) (PubMed:9915839). Observed in all adult tissues tested with strongest expression in kidney, small intestine, spleen, thymus and liver (PubMed:9915839). Moderate expression in brain, stomach, heart, testis, lung, skin, pancreas and skeletal muscle. In brain expressed on capillary endothelia in cerebral cortex. {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:2928113, ECO:0000269|PubMed:9915839}.
Induction：Expression induced by concanavalin-A stimulation. Induced during cell activation but is subsequently maintained at constant levels throughout the cell cycle in exponentially growing cells. {ECO:0000269|PubMed:2928113, ECO:0000269|PubMed:9915839}.
Developmental stage：Strong expression in the liver of 14 dpc embryo and in brain, spleen, liver, kidney and intestine of an 18 dpc embryo. {ECO:0000269|PubMed:9915839}.
Protein families：SLC3A transporter family