CIDEC_MOUSE P56198
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UniProt:P56198
Recommended name：Cell death activator CIDE-3
EC number：
Alternative names：(Cell death-inducing DFFA-like effector protein C) (Fat-specific protein FSP27)
Cleaved into：
GeneID：14311
Gene names (primary )：Cidec
Gene names (synonym )：Fsp27
Gene names (ORF )：
Length：239
Mass：27324
Sequence：MDYAMKSLSLLYPRSLSRHVAVSTAVVTQQLVSKPSRETPRARPCRVSTADRKVRKGIMAHSLEDLLNKVQDILKLKDKPFSLVLEEDGTIVETEEYFQALAKDTMFMVLLKGQKWKPPSEQRKKRAQLALSQKPTKKIDVARVTFDLYKLNPQDFIGCLNVKATLYDTYSLSYDLHCYKAKRIVKEMLRWTLFSMQATGHMLLGTSSYMQQFLDATEEEQPAKAKPSSLLPACLKMLQ
Tissue specificity：Expressed almost exclusively in adipose tissue, including subcutaneous and epididymal white adipose tissue (at protein level). Although abundantly present in brown adipose tissue at the mRNA level, the protein is almost undetectable in this tissue (PubMed:18654663), or at moderate levels (PubMed:22245780, PubMed:12910269). Expressed in the mammary gland, in stromal adipose tissue, but becomes undetectable at the end of pregnancy and during lactation (at protein level). Expressed at low levels in skeletal muscle and heart. {ECO:0000269|PubMed:12910269, ECO:0000269|PubMed:1339452, ECO:0000269|PubMed:18654663, ECO:0000269|PubMed:22245780, ECO:0000269|PubMed:23233732}.
Induction：Up-regulated under conditions that enhance triacylglycerol deposition, including rosiglitazone treatment and high-fat diet. This up-regulation is mediated by PPARG. Up-regulated by isoproterenol, a beta-agonist, and oleic acid treatment. This induction is due to protein stabilization. Down-regulated upon hypertonic conditions. {ECO:0000269|PubMed:18509062, ECO:0000269|PubMed:20089860, ECO:0000269|PubMed:23233732}.
Developmental stage：Up-regulated during differentiation into adipocytes in various cell lines, including TA1 and 3T3-L1. Decreases in the mammary gland during pregnancy from day 14.5 until 18.5, when it becomes hardly detectable, and during lactation. {ECO:0000269|PubMed:1339452, ECO:0000269|PubMed:18334488, ECO:0000269|PubMed:18654663, ECO:0000269|PubMed:22245780}.
Protein families：